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Risperidone treatment of behavioral disturbances in outpatients with dementia.

著者 Irizarry MC , Ghaemi SN , Lee-Cherry ER , Gomez-Isla T , Binetti G , Hyman BT , Growdon JH この記事をPubMed上で見るPubMedで表示
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The authors retrospectively assessed the effectiveness and side effects of risperidone used to treat behavioral disturbances in elderly outpatients with dementia. In 41 patients treated with risperidone 1.8 +/- 1.4 mg/day, there was complete suppression of the target symptom in 15%, partial response in 41%, and no response in 44%. Risperidone appeared equally effective in treating agitation and psychosis. New or worsening extrapyramidal side effects (EPS) occurred in 32%, associated with longer duration of treatment and possibly with concomitant use of serotonergic anti-depressants. Risperidone was a useful adjunct in the treatment of agitation and psychosis in outpatients with dementia but was limited by EPS in about one-third of patients.
PMID: 10440009 [PubMed - indexed for MEDLINE]
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