絞り込み

16641

広告

救急医療管理加算に「重症度スコア」記載を要件化へ (日経BP)

厚生労働省の中央社会保険医療協議会(中医協)は2019年12月4日の総会で、救急医療や小児・周産期医療、癌対策、脳卒中、生活習慣病をテーマに、診療報酬上の評価の...

  1. 導入療法で寛解した55歳以上の急性骨髄性...
  2. 疑問氷解:人間に育てられた犬や猫は、動物...
  3. [医学] 手や腕の動作に携わる脳の運動皮...
  4. SRC/ABLチロシンキナーゼ阻害薬ボス...

ニュース一覧

Expression of the CD69 activation antigen on lymphocytes of patients with hip prosthesis.

著者 Granchi D , Ciapetti G , Savarino L , Stea S , Filippini F , Sudanese A , Rotini R , Giunti A
Biomaterials.2000 Oct ; 21(20):2059-65.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

Dipartimento Putti, Istituti Ortopedici Rizzoli, Bologna, Italy. donatella.granchi@ior.it

スターを付ける スターを付ける     (9view , 0users)

Full Text Sources

The aim of the study was to evaluate the sensitization to metals in patients with Co-Cr hip prosthesis. Peripheral blood mononuclear cells (PBMC) were collected from 14 healthy donors and three groups of patients: 10 candidates for primary total joint replacements, 11 patients with well-fixed implant and 13 patients with aseptic loosening of the hip prosthesis. PBMCs were cultured with the metal ions employed for implant manufacturing and the expression of CD69 activation antigen on CD3/T lymphocytes was detected by flow cytometry. Chromium extract increased significantly the expression of CD3/CD69 phenotype in patients with loosening of hip prosthesis. The chromium-induced 'activation index' was higher in patients with loosening of hip prosthesis than in healthy donors and in pre-implant patients. The cobalt-stimulated PBMC of patients with either well-fixed or loosened prosthesis had an 'activation index' significantly higher than healthy donors. The activation index values were used to graduate the PBMC-response as 'normal' (> or = 0.9 and < 2), 'low' (< 0.9) and 'high' (> or = 2): an high-activation index was observed only in chromium-exposed PBMC of patients with prosthesis. Our data show that chromium released from orthopedic implants could be responsible for the lymphocyte sensitization and flow cytometry is an easy and reliable method for monitoring the hypersensitivity state in patients with metal prostheses. Activated lymphocytes in the peri-implant tissue are likely to elicit a localized immune response and contribute to maintain the inflammatory process evolving in the implant failure.
PMID: 10966015 [PubMed - indexed for MEDLINE]
印刷用ページを開く Endnote用テキストダウンロード