絞り込み

16640

広告

ダビンチ没後500年記念 最大規模の特別展 仏ルーブル美術館

ルネサンスの巨匠、レオナルド・ダビンチの没後500年を記念して、世界中からダビンチやその弟子たちの作品を集めた過去最大規模の特別展が、24日からフランスのルーブ...

  1. [企業] Provention Bio社...
  2. クルド人はどんな人たち? 4カ国に暮らす...
  3. インフルエンザ新防御機構を東大が解明、効...
  4. ニホンザル 餌を得るため2匹が協力 初め...

ニュース一覧

Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage.

著者 Pichierri P , Franchitto A , Mosesso P , Palitti F
Mutat Res.2000 Nov 30 ; 456(1-2):45-57.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

Università degli Studi della Tuscia, DABAC, Laboratorio di Citogenetica Molecolare e Mutagenesi, Via S. Camillo de Lellis, I-01100 Viterbo, Italy.

スターを付ける スターを付ける     (92view , 0users)

Full Text Sources

Medical

Miscellaneous

Molecular Biology Databases

Werner's syndrome (WS) is a recessive human genetic disorder associated with an elevated incidence of many types of cancer. The WS gene product, WRNp, belongs to the RecQ family of DNA helicases and is required for the maintenance of genomic stability in human cells. A possible interaction between helicases and topoisomerases that could co-operate in many aspects of DNA metabolism such as progression of the replication forks, recombination and repair has been recently suggested. In addition, sgs1 gene product in yeast, homologous to WS gene, has been shown to physically interact with topoisomerase types I and II. Earlier data from our laboratory suggested that WRN helicase might play a role in a G2 recombinational pathway of double strand breaks (DSBs) repair, co-operating with topoisomerase II. In this work, the effect of the topoisomerase I inhibitor camptothecin in WS cells has been investigated at the chromosomal level. The data from the present work suggest that the inhibition of topoisomerase I activity by camptothecin results in a higher induction of chromosomal damage in WS cell lines in the G2-phase and in the S-phase of the cell cycle compared to normal cells, perhaps associated with the defects in DNA replication synthesis.
PMID: 11087895 [PubMed - indexed for MEDLINE]
印刷用ページを開く Endnote用テキストダウンロード