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Investigation of G2-phase chromosomal radiosensitivity in hereditary non-polyposis colorectal cancer cells.

著者 Franchitto A , Pichierri P , Genuardi M , De Santis A , Palitti F
Int J Radiat Biol.2001 Jul ; 77(7):773-80.
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Laboratorio di Citogenetica Molecolare e Mutagenesi - DABAC, Università degli Studi della Tuscia, Via S. Camillo de Lellis, I-01100 Viterbo, Italy.

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To investigate whether cells from hereditary nonpolyposis colorectal cancer (HNPCC) patients, a genetic condition characterized by constitutional mutations in DNA mismatch repair genes and associated with predisposition to colorectal carcinoma (CRC), could present a higher G2 chromosomal radiosensitivity. It is generally hypothesized that cancer predisposition in HNPCC is associated with the loss of the wild-type allele in somatic cells, resulting in defective DNA mismatch repair but, to date, no data on G2 radiosensitivity have been reported for HNPCC.
PMID: 11454277 [PubMed - indexed for MEDLINE]
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