絞り込み

16610

広告

「現役女子高生 ピル飲んでます」誤解解いて ツイートに反響 (NHK)

女性の生理の痛みなどを和らげる治療薬としての低用量ピル。しかし避妊目的のイメージが強く、生理痛の治療に使うことが知られていないため、つらい思いをしたと訴える女子...

  1. ペンギンたちが大集合 (日経BP)
  2. [医学] 32の抗精神病薬の統合失調症治...
  3. 薬局で妊産婦の薬の一元的・継続的な把握を...
  4. 薬を交付した薬局薬剤師の言い分 (日経B...

ニュース一覧

Calmodulin kinase and L-type calcium channels; a recipe for arrhythmias?

著者 Anderson ME
Trends Cardiovasc Med.2004 May ; 14(4):152-61.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

Division of Cardiovascular Medicine, Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, 383 Preston Research Building, 2220 Pierce Avenue, Nashville, TN 37232-6300, USA. mark.anderson@vanderbilt.edu

スターを付ける スターを付ける     (1,563view , 0users)

Full Text Sources

Medical

Miscellaneous

L-type Ca2+ channels (LTCCs) are the main portal for Ca2+ entry into cardiac myocytes. These ion channel proteins open in response to cell membrane depolarizations elicited by action potentials, and LTCC current (I(Ca)) flows during the action potential plateau, to increase cellular Ca2+ (Ca2+(i)) and trigger myocardial contraction. I(Ca) is also implicated in the genesis of cardiac arrhythmias under conditions such as heart failure and cardiac hypertrophy, in which the action potential plateau and QT interval are prolonged. This article reviews recent findings about the molecular regulation of LTCCs by the Ca2+-dependent signaling molecule, calmodulin kinase II (CaMKII), and compares this form of regulation with regulation by calmodulin-binding domains and beta-adrenergic receptor agonists. LTCC dysregulation is discussed in the context of new results showing that CaMKII can be a proarrhythmic signal in disease conditions in which Ca2+(i) is disordered and cardiac repolarization is excessively prolonged.
PMID: 15177266 [PubMed - indexed for MEDLINE]
印刷用ページを開く Endnote用テキストダウンロード