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Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy.

著者 Gurol ME , Irizarry MC , Smith EE , Raju S , Diaz-Arrastia R , Bottiglieri T , Rosand J , Growdon JH , Greenberg SM
Neurology.2006 Jan 10 ; 66(1):23-9.
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Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.

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Microvascular brain injury, typically measured by extent of white matter hyperintensity (WMH) on MRI, is an important contributor to cognitive impairment in the elderly. Recent studies suggest a role for circulating beta-amyloid peptide in microvascular dysfunction and white matter disease.
PMID: 16401840 [PubMed - indexed for MEDLINE]
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