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Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report.

著者 Bacskai BJ , Frosch MP , Freeman SH , Raymond SB , Augustinack JC , Johnson KA , Irizarry MC , Klunk WE , Mathis CA , Dekosky ST , Greenberg SM , Hyman BT , Growdon JH
Arch Neurol.2007 Mar ; 64(3):431-4.
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MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Charlestown, MA 02129, USA. bbacskai@partners.org

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To determine the correspondence between uptake of Pittsburgh Compound B (PiB) in life and measures of beta-amyloid (Abeta) in postmortem tissue analysis. Patient A 76-year-old man with a clinical diagnosis of dementia with Lewy bodies underwent fluorodeoxyglucose (18)F and PiB positron emission tomographic brain scans. Imaging revealed marked region specific binding of PiB and abnormal fluorodeoxyglucose uptake. Intervention Autopsy was performed 3 months after the PiB scan.
PMID: 17353389 [PubMed - indexed for MEDLINE]
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