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The role of cyclooxygenase-2/prostanoid pathway in visceral pain induced liver stress response in rats.

著者 Piston D , Wang S , Feng Y , Ye YJ , Zhou J , Jiang KW , Xu F , Zhao Y , Cui ZR
Chin Med J (Engl).2007 Oct 20 ; 120(20):1813-9.
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Cyclooxygenase (COX) is the rate-limiting enzyme in the production of prostanoids from arachidonic acid. COX-2 is the inducible enzyme in the COX family, together with the prostanoids forms the COX-2/prostanoid pathway. Research showed that the COX-2/prostanoid pathway is activated in hepatic diseases and liver stress reaction, such as fibrogenesis, portal hypertension, carcinogenesis, and ischemic/reperfusion injury. But there was no report on visceral pain induced liver stress. This study was to investigate the role of the COX-2/prostanoid pathway in liver stress response in rat acute colitis visceral pain liver stress model.
PMID: 18028778 [PubMed - indexed for MEDLINE]
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