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Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health study.

著者 Grodstein F , van Oijen M , Irizarry MC , Rosas HD , Hyman BT , Growdon JH , De Vivo I
PLoS One.2008 Feb 13 ; 3(2):e1590.
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Dementia takes decades to develop, and effective prevention will likely require early intervention. Thus, it is critical to identify biomarkers of preclinical disease, allowing targeting of high-risk subjects for preventive efforts. Since telomeres shorten with age and oxidative stress, both of which are important contributors to the onset of dementia, telomere length might be a valuable biomarker.
PMID: 18795148 [PubMed - indexed for MEDLINE]
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