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Direct MRI mapping of neuronal activity evoked by electrical stimulation of the median nerve at the right wrist.

著者 Xue Y , Chen X , Grabowski T , Xiong J
Magn Reson Med.2009 May ; 61(5):1073-82.
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Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa 52242, USA.

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Magnetic source MRI (msMRI) has being developed recently for direct detections of neuronal magnetic fields to map brain activity. However, controversial results have been reported by different research groups. In this study, more evidence was provided to demonstrate that the neuronal current signal could be detected by MRI using a rapid median nerve stimulation paradigm. The experiments were performed on six normal human participants to investigate the temporal specificity of the effect, as well as inter- and intrasubject reproducibility. Significant activation of contralateral primary sensory cortex (S1) was detected 80 ms after stimulation onset (corresponding to the P80 evoked potential peak). The 80-ms latency S1 activation was observed over three independent sessions for one subject and for all six participants. The magnitude of the signal change was 0.2-0.3%. Coinciding with our expectations, no S1 activation was found when MRI data acquisitions were targeted at the N20 and P30 peaks because of mutual cancellation of magnetic fields generated by those peaks. The results demonstrated good reproducibility of S1 activations and indicated that the S1 activations most likely originated from neuronal magnetic field rather than hemodynamic response.
PMID: 19466755 [PubMed - indexed for MEDLINE]
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