PMID- 20214328 OWN - NLM STAT- In-Process DA - 20100310 IS - 1003-5370 (Print) VI - 29 IP - 12 DP - 2009 Dec TI - [Effect of qingre quyu granule on the vulnerable atherosolerotic plaque of carotid artery in patients with stable coronary artery disease] PG - 1085-8 AB - OBJECTIVE: To investigate the effect of qingre quyu granule (QQG) for treatment of carotid vulnerable atherosclerotic plaque (CVAP) in patients with coronary heart disease (CHD). METHODS: Eighty-two CHD patients with stable exertional angina, complicated with CVAP and differentiated to phlegm-heat and blood-stasis syndrome type were randomly assigned to two groups equally, the test group treated by Western medical routine therapy combined with QQG, and the control group treated with Western medical routine therapy with placebo. Using high frequency ultrasonography, the number (complex and simple) and Crouse integral of CVAP and the intima-media membranous thickness of carotid artery were measured, and changes in serum levels of CD40L and high-sensitivity C-reactive protein (hs-CRP), liver and renal functions were observed. RESULTS: After treatment, significant improvement were shown in the test group in terms of complex plaques' number, Crouse integral, intima-media thickness and serum levels of CD40L and hs-CRP as compared with that before treatment, also with those in the control group after treatment (P < 0.05 or P < 0.01). No adverse reaction was found in the treatment course. CONCLUSION: QQG has certain stabilizing action on CVAP in patients with CHD. AD - Department of National Integrative Medicine Center for Cardiovascular Diseases, China-Japan Friendship Hospital of Ministry of Public Health, Beijing. FAU - Cheng Wen-li AU - Cheng WL FAU - Wang Yong AU - Wang Y FAU - Cai Zhe AU - Cai Z LA - chi PT - English Abstract PT - Journal Article PL - China TA - Zhongguo Zhong Xi Yi Jie He Za Zhi JT - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban JID - 9211576 SB - IM EDAT- 2010/03/11 06:00 MHDA- 2010/03/11 06:00 CRDT- 2010/03/11 06:00 PST - ppublish SO - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Dec ; 29(12):1085-8.