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Gαo represses insulin secretion by reducing vesicular docking in pancreatic beta-cells.

著者 Zhao A , Ohara-Imaizumi M , Brissova M , Benninger RK , Xu Y , Hao Y , Abramowitz J , Boulay G , Powers AC , Piston D , Jiang M , Nagamatsu S , Birnbaumer L , Gu G
Diabetes.2010 Oct ; 59(10):2522-9.
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Pertussis toxin uncoupling-based studies have shown that Gαi and Gαo can inhibit insulin secretion in pancreatic β-cells. Yet it is unclear whether Gαi and Gαo operate through identical mechanisms and how these G-protein-mediated signals inhibit insulin secretion in vivo. Our objective is to examine whether/how Gαo regulates islet development and insulin secretion in β-cells.
PMID: 20622165 [PubMed - indexed for MEDLINE]
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