絞り込み

16391

広告

Exogenous coproporphyrin III production from Corynebacterium aurimucosum and Microbacterium oxydans in erythrasma lesions.

著者 Yasuma A , Ochiai T , Azuma M , Nishiyama H , Kikuchi K , Kondo M , Handa H
J Med Microbiol.2011 Mar 10 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

1 Surugadai Nihon University Hospital;

スターを付ける スターを付ける     (344view , 0users)
  • このエントリーをはてなブックマークに追加

Full Text Sources

Erythrasma is a superficial skin disease caused by Gram-positive Corynebacterium species. Coral-red fluorescence under Wood's light, strongly suggestive of erythrasma, can be attributed to the presence of porphyrins. Fractionated porphyrin analysis in erythrasma lesions is yet to be reported. We attempted to investigate erythrasma lesions by isolating the responsible bacteria and determining their exogenous porphyrin production by high performance liquid chromatography (HPLC) analysis. We observed a 78-year-old woman with erythrasma who had a well-demarcated slightly scaling patch on her left foot, between the fourth and fifth toes. Two kinds of colonies on 5% sheep blood agar were obtained from this lesion. Analysis of the 16S ribosomal RNA sequence revealed the colonies to be Corynebacterium aurimucosum and Microbacterium oxydans. HPLC analysis demonstrated that coproporphyrin III (CPIII) levels were clearly elevated, although the amounts of protoporphyrin were diminished. These results indicate that the fluorescent substance was CPIII. This study supports the view that excess CPIII synthesis by C. aurimucosum and M. oxydans leads to accumulation of porphyrin in cutaneous tissue, which emits a coral-red fluorescence when exposed to Wood's light.
PMID: 21393451 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード