絞り込み

16514

広告

7原発12基 中央制御室の換気用ダクトに穴や腐食 (NHK)

原子力規制委員会は23日、新潟県にある柏崎刈羽原子力発電所など全国の7原発12基で中央制御室の換気用のダクトに穴や腐食が見つかったことを公表しました。電力各社は...

  1. ツキノワグマのすむ森で?徳島県中部で計画...
  2. [企業] ImmusanT セリアック病...
  3. 囲碁 本因坊戦で江戸時代の対局再現 京都...
  4. 最初期のバイオリン、人の声に似せて製作 ...

ニュース一覧

Gain of chromosome band 7q11 in papillary thyroid carcinomas of young patients is associated with exposure to low-dose irradiation.

著者 Heß J , Thomas G , Braselmann H , Bauer V , Bogdanova T , Wienberg J , Zitzelsberger H , Unger K
Proc Natl Acad Sci U S A.2011 May 23 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

Research Unit of Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany.

スターを付ける スターを付ける     (24,010view , 1users)

Full Text Sources

Other Literature Sources

The main consequence of the Chernobyl accident has been an increase in papillary thyroid carcinomas (PTCs) in those exposed to radioactive fallout as young children. Our aim was to identify genomic alterations that are associated with exposure to radiation. We used array comparative genomic hybridization to analyze a main (n = 52) and a validation cohort (n = 28) of PTC from patients aged <25 y at operation and matched for age at diagnosis and residency. Both cohorts consisted of patients exposed and not exposed to radioiodine fallout. The study showed association of a gain on chromosome 7 (7q11.22-11.23) with exposure (false discovery rate = 0.035). Thirty-nine percent of the exposed group showed the alteration; however, it was not found in a single case from the unexposed group. This was confirmed in the validation set. Because only a subgroup of cases in the exposed groups showed gain of 7q11.22-11.23, it is likely that different molecular subgroups and routes of radiation-induced carcinogenesis exist. The candidate gene CLIP2 was specifically overexpressed in the exposed cases. In addition, the expression of the genes PMS2L11, PMS2L3, and STAG3L3 correlated with gain of 7q11.22-11.23. An enrichment of Gene Ontology terms "DNA repair" (PMS2L3, PMS2L5), "response to DNA damage stimulus" (BAZ1B, PMS2L3, PMS2L5, RFC2), and "cell-cell adhesion" (CLDN3, CLDN4) was found. This study, using matched exposed and unexposed cohorts, provides insights into the radiation-related carcinogenesis of young-onset PTC and, with the exposure-specific gain of 7q11 and overexpression of the CLIP2 gene, radiation-specific molecular markers.
PMID: 21606360 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード