絞り込み

16506

広告

愛知 新たに幼女がはしか感染 沖縄は患者70人に (NHK)

「はしか」の感染が広がる中、愛知県内では新たに1歳の女の子の感染が確認される一方、沖縄県内では24日までに患者の数が70人に上っています。 愛知県内では、今月沖...

  1. [医学] 活動量計の装着と通話で歩行を促...
  2. 米退役軍人長官候補の指名公聴会延期、「指...
  3. [医学] 出産後12週間(妊産婦4期)の...
  4. 「買収合意」報道も乱れ飛ぶ武田薬品のSh...

ニュース一覧

Post-translational isoprenylation of tryptophan.

著者 Okada M
Biosci Biotechnol Biochem.2011 ; 75(8):1413-7.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

Department of Chemistry, Graduate School of Science, Tohoku University, Aooba-ku, Sendai, Japan. okada@isc.chubu.ac.jp

スターを付ける スターを付ける     (5,956view , 0users)

Full Text Sources

Miscellaneous

Bacillus subtilis and related bacilli produce a post-translationally modified oligopeptide, ComX pheromone, that stimulates natural genetic competence controlled by quorum sensing. The ComX pheromones are formed by geranylation or farnesylation on a tryptophan residue at the 3 position of its indole ring. This results in the formation of a tricyclic structure including, a newly formed five-membered ring, similar to proline. Isoprenylation of ComX to form ComX pheromones is essential for pheromonal activity, and is functionally more crucial than its amino acid sequence. The ComX pheromone is the first example of isoprenoidal modifiations of tryptophan residues in living organisms and post-translational isoprenylation of any amino acid in prokaryotes. Because the presence of geranylated compounds is unusual in primary and secondary metabolites outside the plant kingdom, post-translational geranylation in bacilli is unprecedented in nature.
PMID: 21821957 [PubMed - indexed for MEDLINE]
印刷用ページを開く Endnote用テキストダウンロード