絞り込み

16532

広告

Detoxification of Methylmercury by Hydrogen Sulfide Producing Enzyme in Mammalian Cells.

著者 Yoshida E , Toyama T , Shinkai Y , Sawa T , Akaike T , Kumagai Y
Chem Res Toxicol.2011 Sep 27 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (1,017view , 0users)

Full Text Sources

Miscellaneous

Methylmercury (MeHg) covalently modifies cellular proteins through their SH groups, resulting in cytotoxicity. We report that cystathionine β-synthase (CBS), which catalyzes production of hydrogen sulfide, contributes to cellular protection against MeHg. Pretreatment with NaHS or overexpression of CBS reduced MeHg cytotoxicity, whereas transfection with CBS small interfering RNA enhanced MeHg toxicity in human neuroblastoma SH-SY5Y cells. Bismethylmercury sulfide ((MeHg)<sub>2</sub>S) was identified as a metabolite of MeHg in SH-SY5Y cells exposed to MeHg and in the livers of rats treated with MeHg. (MeHg)<sub>2</sub>S had little chemical protein modification capability and little cytotoxicity compared with MeHg <i>in vitro</i> and <i>in vivo</i>.
PMID: 21951228 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード