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Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission.

著者 Okuda-Ashitaka E , Minami T , Tsubouchi S , Kiyonari H , Iwamatsu A , Noda T , Handa H , Ito S
J Biol Chem.2012 Feb 6 ; ():.
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Osaka Institute of Technology, Japan;

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4-Nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1) is a molecule of physiologically unknown function, although it is predominantly expressed in brain, spinal cord, liver and kidney. We identified NIPSNAP1 as a protein that interacts with the neuropeptide nocistatin (NST) from synaptosomal membranes of mouse spinal cord using high-performance affinity latex beads. NST, which is produced from the same precursor protein as an opioid-like neuropeptide nociceptin/orphanin FQ (N/OFQ), has opposite effects on pain transmission evoked by N/OFQ. The calculated full-length pre-protein of NIPSNAP1 was 33 kDa, whereas the N-terminal truncated form of NIPSNAP1 (29 kDa) was ubiquitously expressed in the neuronal tissues, especially in synaptic membrane and mitochondria of brain. The 29-kDa NIPSNAP1 was distributed on the cell-surface, and NST interacted with the 29-kDa NIPSNAP1 but not the 33-kDa one. Although intrathecal injection of N/OFQ induced tactile allodynia in both wild-type and NIPSNAP1-deficient mice, the inhibition of N/OFQ-evoked tactile allodynia by NST seen in wild-type mice was completely lacking in the deficient mice. These results suggest that NIPSNAP1 is an interacting molecule of NST and plays a crucial role in pain transmission.
PMID: 22311985 [PubMed - as supplied by publisher]
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