Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
Okada Y , Terao C , Ikari K , Kochi Y , Ohmura K , Suzuki A , Kawaguchi T , Stahl EA , Kurreeman FA , Nishida N , Ohmiya H , Myouzen K , Takahashi M , Sawada T , Nishioka Y , Yukioka M , Matsubara T , Wakitani S , Teshima R , Tohma S , Takasugi K , Shimad
Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation. We report a meta-analysis of genome-wide association studies (GWAS) in a Japanese population including 4,074 individuals with rheumatoid arthritis (cases) and 16,891 controls, followed by a replication in 5,277 rheumatoid arthritis cases and 21,684 controls. Our study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 × 10(-8), including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2. ANXA3 was also associated with susceptibility to systemic lupus erythematosus (P = 0.0040), and B3GNT2 and ARID5B were associated with Graves' disease (P = 3.5 × 10(-4) and 2.9 × 10(-4), respectively). We conducted a multi-ancestry comparative analysis with a previous meta-analysis in individuals of European descent (5,539 rheumatoid arthritis cases and 20,169 controls). This provided evidence of shared genetic risks of rheumatoid arthritis between the populations.
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