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Substantia nigra volume loss before basal forebrain degeneration in early Parkinson disease.

著者 Ziegler DA , Wonderlick JS , Ashourian P , Hansen LA , Young JC , Murphy AJ , Koppuzha CK , Growdon JH , Corkin S
JAMA Neurol.2013 Feb ; 70(2):241-7.
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To test the hypothesis that degeneration of the substantia nigra pars compacta (SNc) precedes that of the cholinergic basal forebrain (BF) in Parkinson disease (PD) using new multispectral structural magnetic resonance (MR) imaging tools to measure the volumes of the SNc and BF.
PMID: 23183921 [PubMed - indexed for MEDLINE]
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