絞り込み

16424

広告

こんぴら歌舞伎へ 八代目中村芝翫さんが意気込み (NHK)

香川県琴平町にある国内最古の芝居小屋で毎年春に行われる「四国こんぴら歌舞伎大芝居」の製作発表の会見が24日、東京で開かれ、襲名披露の公演となる八代目中村芝翫さん...

  1. ~日本とベトナム 再生医療技術協力が拡大...
  2. 「火山は日本にとって恵みだ」。 知の巨人...
  3. 乾癬治療、新しい飲み薬が四半世紀ぶり登場...
  4. 太地町イルカ追い込みで姉妹都市 (デイリ...

ニュース一覧

Vitamin K2 Covalently Binds to Bak and Induces Bak-Mediated Apoptosis.

著者 Karasawa S , Azuma M , Kasama T , Sakamoto S , Kabe Y , Imai T , Yamaguchi Y , Miyazawa K , Handa H
Mol Pharmacol.2012 Dec 10 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

1 Tokyo Institute of Technology;

スターを付ける スターを付ける     (340view , 0users)

Full Text Sources

Miscellaneous

Vitamin K2 (VK2, menaquinone) is known to have anticancer activity in vitro and in vivo. Although its effect is thought to be mediated, at least in part, by the induction of apoptosis, the underlying molecular mechanism remains elusive. Here, we identified Bcl-2 antagonist killer 1 (Bak) as a molecular target of VK2-induced apoptosis. VK2 directly interacts with Bak and induces mitochondrial-mediated apoptosis. Although Bak and Bax, another member of the Bcl-2 family, are generally thought to be functionally redundant, only Bak is necessary and sufficient for VK2-induced cytochrome c release and cell death. Moreover, VK2-2,3 epoxide, an intracellular metabolite of VK2, was shown to covalently bind to the cysteine-166 residue of Bak. Several lines of evidence suggested that the covalent attachment of VK2 is critical for apoptosis induction. Thus, this study reveals a specific role for Bak in mitochondria-mediated apoptosis. This study also provides insight into the anticancer effects of VK2 and suggests that Bak may be a potential target of cancer therapy.
PMID: 23229512 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード