絞り込み

16424

広告

こんぴら歌舞伎へ 八代目中村芝翫さんが意気込み (NHK)

香川県琴平町にある国内最古の芝居小屋で毎年春に行われる「四国こんぴら歌舞伎大芝居」の製作発表の会見が24日、東京で開かれ、襲名披露の公演となる八代目中村芝翫さん...

  1. ~日本とベトナム 再生医療技術協力が拡大...
  2. 「火山は日本にとって恵みだ」。 知の巨人...
  3. 乾癬治療、新しい飲み薬が四半世紀ぶり登場...
  4. 太地町イルカ追い込みで姉妹都市 (デイリ...

ニュース一覧

In vivo identification of sentinel lymph nodes using MRI and size-controlled and monodispersed magnetite nanoparticles.

著者 Iida S , Imai K , Matsuda S , Itano O , Hatakeyama M , Sakamoto S , Kokuryo D , Okabayashi K , Endo T , Ishii Y , Hasegawa H , Aoki I , Handa H , Kitagawa Y
J Magn Reson Imaging.2013 Apr 1 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

Department of Surgery, School of Medicine, Keio University, Tokyo, Japan.

スターを付ける スターを付ける     (348view , 0users)

Full Text Sources

Medical

PURPOSE: To develop a sentinel lymph node (SN) identification method using accurately synthesized magnetic nanoparticles (MNPs), as an enhanced specific SN tracer in combination with magnetic resonance imaging (MRI) in intact rodent and SN metastasis models. MATERIALS AND METHODS: Three sizes of MNPs were originally synthesized. We developed an experimental rat SN model, with brachial lymph nodes (Br) as the SN and the axillary lymph node (Ax) as the second lymph node, and injection of MNPs via the front paw. SN detectability was evaluated in vivo using T1 -weighted MR images after injection of the synthesized MNPs, and the amount of iron in the Br and in the Ax was assessed using inductively coupled plasma optical emission spectrometry. RESULTS: The highest ratios of the amount of iron in the Br versus the Ax were 3.1 and 3.3, using 20-nm MNPs after 2- and 24-hour injections. The appropriate dose and particle diameter for MRI detection was optimized, and the SN was optimally distinguished in the normal and metastatic rat models using MRI after a 0.4 mg/kg 20-nm MNP injection. CONCLUSION: We developed and optimized a useful SN identification method using MRI in rodent models. J. Magn. Reson. Imaging 2013;. © 2013 Wiley Periodicals, Inc.
PMID: 23554026 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード