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新種の光るクモヒトデ発見…中部大チーム、海底洞窟で (読売新聞)

オーストラリアのクリスマス島の海底洞窟で、新種の光るクモヒトデを発見したと、中部大の大場裕一教授(発光生物学)らの研究チームが発表した。シンガポールの学術誌に論...

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Tissue stiffness dictates development, homeostasis, and disease progression.

著者 Handorf AM , Zhou Y , Halanski MA , Li WJ
Organogenesis.2015 Jan 2 ; 11(1):1-15.
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Tissue development is orchestrated by the coordinated activities of both chemical and physical regulators. While much attention has been given to the role that chemical regulators play in driving development, researchers have recently begun to elucidate the important role that the mechanical properties of the extracellular environment play. For instance, the stiffness of the extracellular environment has a role in orienting cell division, maintaining tissue boundaries, directing cell migration, and driving differentiation. In addition, extracellular matrix stiffness is important for maintaining normal tissue homeostasis, and when matrix mechanics become imbalanced, disease progression may ensue. In this article, we will review the important role that matrix stiffness plays in dictating cell behavior during development, tissue homeostasis, and disease progression.
PMID: 25915734 [PubMed - in process]
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