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Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores.

著者 Lepage ML , Mirloup A , Ripoll M , Stauffert F , Bodlenner A , Ziessel R , Compain P
Beilstein J Org Chem.2015 ; 11():659-67.
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The synthesis and photophysical properties of the first examples of iminosugar clusters based on a BODIPY or a pyrene core are reported. The tri- and tetravalent systems designed as molecular probes and synthesized by way of Cu(I)-catalysed azide-alkyne cycloadditions are fluorescent analogues of potent pharmacological chaperones/correctors recently reported in the field of Gaucher disease and cystic fibrosis, two rare genetic diseases caused by protein misfolding.
PMID: 26124868 [PubMed]
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