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A 2-Step Haploidentical Versus A 2-Step Matched Related Allogeneic Myeloablative Peripheral Blood Stem Cell Transplantation.

著者 Gaballa S , Palmisiano N , Alpdogan O , Carabasi M , Filicko-O'Hara J , Kasner M , Kraft WK , Leiby B , Martinez-Outschoorn U , O'Hara W , Pro B , Rudolph S , Sharma M , Wagner JL , Weiss M , Flomenberg N , Grosso D この記事をPubMed上で見るPubMedで表示
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Haploidentical (HI) stem cell transplantation (SCT) offers a transplant option to patients who lack an HLA matched donor. We developed a 2-step approach to myeloablative allogeneic hematopoietic stem cell transplantation for patients with haploidentical or matched related (MR) donors. In this approach, the lymphoid and myeloid portions of the graft are administered in two separate steps to allow fixed T cell dosing. Cyclophosphamide (CY) is used for T cell tolerization. Given a uniform conditioning regimen, graft T-cell dose, and GVHD prophylaxis strategy, we compared immune reconstitution and clinical outcomes in patients undergoing 2-step HI vs. 2-step MR SCT.
PMID: 26415558 [PubMed - as supplied by publisher]
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