絞り込み

18361

広告

AI実用化の本道 走りながらガードレールの点検効率化 教師データは? (財経新聞)

凸版印刷は、イクシス(川崎市)およびケー・エフ・シー(大阪市)と共同開発した人工知能(AI)を使い、ガードレール支柱の腐食を走行しながら点検できるシステムを発表...

  1. 血液型不適合移植と異種移植の拒絶反応を抑...
  2. [企業] ESMO20 膵臓神経内分泌腫...
  3. [企業] ESMO20 初期乳癌術後のP...
  4. 町全体がまるで博物館、崩落を続けるイタリ...

ニュース一覧

DNA methylation levels of α-synuclein intron 1 in the aging brain.

著者 de Boni L , Riedel L , Schmitt I , Kraus TF , Kaut O , Piston D , Akbarian S , Wüllner U
Neurobiol Aging.2015 Sep 8 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (5view , 0users)
DNA methylation patterns change with age, and aging itself is a major confounding risk factor for Parkinson's disease (PD). Duplication and triplication, that is, increased expression of the α-synuclein (SNCA) gene, cause familial PD, and demethylation of SNCA intron 1 has been shown to result in increased expression of SNCA. We thus hypothesized that age-related alterations of SNCA methylation might underly the increased susceptibility toward PD in later life. The present study sought to determine (1) whether alterations of SNCA intron 1 methylation occurred during aging, (2) whether the methylation pattern differed between men and women, and (3) whether purified neurons compared with non-neuronal cells exhibited different methylation patterns. The analysis of DNA from brain tissue and fluorescence activated cell sorting-sorted purified neurons of 41 individuals revealed only a minor increase of SNCA intron 1 DNA methylation levels in presumably healthy individuals during aging but no significant difference between men and women. Interestingly enough, methylation of SNCA intron 1 was higher in neurons compared with non-neuronal cells, although non-neuronal cells express lower levels of SNCA. Therefore, the normal pattern of SNCA methylation during aging should not result in increased expression of α-synuclein protein. It is thus likely that additional, yet not identified, mechanisms contribute to the tissue specificity of SNCA expression and the presumed dysregulation in PD.
PMID: 26422361 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード