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Genetic disruption of Ano5 in mice does not recapitulate human ANO5-deficient muscular dystrophy.

著者 Xu J , El Refaey M , Xu L , Zhao L , Gao Y , Floyd K , Karaze T , Janssen PM , Han R
Skelet Muscle.2015 ; 5():43.
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Anoctamin 5 (ANO5) is a member of a conserved gene family (TMEM16), which codes for proteins predicted to have eight transmembrane domains and putative Ca(2+)-activated chloride channel (CaCC) activity. It was recently reported that mutations in this gene result in the development of limb girdle muscular dystrophy type 2L (LGMD2L), Miyoshi myopathy type 3 (MMD3), or gnathodiaphyseal dysplasia 1 (GDD1). Currently, there is a lack of animal models for the study of the physiological function of Ano5 and the disease pathology in its absence.
PMID: 26693275 [PubMed]
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