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Core Fucosylation on T cells, Required for Activation of T-cell Receptor Signaling and Induction of Colitis in Mice, is Increased in Patients with Inflammatory Bowel Disease.

著者 Fujii H , Shinzaki S , Iijima H , Wakamatsu K , Iwamoto C , Sobajima T , Kuwahara R , Hiyama S , Hayashi Y , Takamatsu S , Uozumi N , Kamada Y , Tsujii M , Taniguchi N , Takehara T , Miyoshi E
Gastroenterology.2016 Mar 7 ; ():.
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Attachment of a fucose molecule to the innermost N-glycan in a glycoprotein (core fucosylation) regulates the activity of many growth factor receptors and adhesion molecules. The process is catalyzed by α1-6 fucosyltransferase (FUT8) and required for immune regulation, but it is not clear whether this process is dysregulated during disease pathogenesis. We investigated whether core fucosylation regulates T-cell activation and induction of colitis in mice, and is altered in patients with inflammatory bowel disease (IBD).
PMID: 26965517 [PubMed - as supplied by publisher]
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