絞り込み

16641

広告

「医療マンガ大賞」、受賞作品が決定 (日経BP)

神奈川県横浜市は今年、医療広報の一環として、漫画を活用した取り組み「医療マンガ大賞」を創設した(関連記事:医師と患者のギャップを埋める「医療マンガ大賞」創設)。...

  1. タイの大型肉食恐竜、新種と判明 (デイリ...
  2. 映画を通じた交流を 大阪韓国映画祭始まる...
  3. だんだん小さく、やがて視野の外…「さよな...
  4. 新種の大型肉食恐竜「シャムラプトル・スワ...

ニュース一覧

WRNIP1 protects stalled forks from degradation and promotes fork restart after replication stress.

著者 Leuzzi G , Marabitti V , Pichierri P , Franchitto A
EMBO J.2016 May 30 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (355view , 0users)

Full Text Sources

Miscellaneous

Accurate handling of stalled replication forks is crucial for the maintenance of genome stability. RAD51 defends stalled replication forks from nucleolytic attack, which otherwise can threaten genome stability. However, the identity of other factors that can collaborate with RAD51 in this task is poorly elucidated. Here, we establish that human Werner helicase interacting protein 1 (WRNIP1) is localized to stalled replication forks and cooperates with RAD51 to safeguard fork integrity. We show that WRNIP1 is directly involved in preventing uncontrolled MRE11-mediated degradation of stalled replication forks by promoting RAD51 stabilization on ssDNA We further demonstrate that replication fork protection does not require the ATPase activity of WRNIP1 that is however essential to achieve the recovery of perturbed replication forks. Loss of WRNIP1 or its catalytic activity causes extensive DNA damage and chromosomal aberrations. Intriguingly, downregulation of the anti-recombinase FBH1 can compensate for loss of WRNIP1 activity, since it attenuates replication fork degradation and chromosomal aberrations in WRNIP1-deficient cells. Therefore, these findings unveil a unique role for WRNIP1 as a replication fork-protective factor in maintaining genome stability.
PMID: 27242363 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード