絞り込み

16644

広告

新型肺炎 外務省の渡航中止勧告受け日本企業が対応強化 (NHK)

外務省が日本人を対象に出している「感染症危険情報」のうち、湖北省全体の危険レベルを引き上げ、渡航の中止を勧告したことを受けて日本企業も対応を強化しています。 こ...

  1. [医学] 高蛋白質食はmTOR伝達を煽っ...
  2. 新型肺炎 中国 感染拡大防止へ厳戒態勢の...
  3. フィリピン 中国人観光客460人余送還へ...
  4. 原子力審議会議事録の言葉を分析 (デイリ...

ニュース一覧

スターを付ける スターを付ける     (564view , 0users)

Full Text Sources

Miscellaneous

Molecular Biology Databases

PhosphoSitePlus® - comprehensive post-translational modification resource

Other Literature Sources

Regulation of end-processing is critical for accurate repair and to switch between homologous recombination (HR) and non-homologous end joining (NHEJ). End resection is a two-stage process but very little is known about regulation of the long-range resection, especially in humans. WRN participates in one of the two alternative long-range resection pathways mediated by DNA2 or EXO1. Here we demonstrate that phosphorylation of WRN by CDK1 is essential to perform DNA2-dependent end resection at replication-related DSBs, promoting HR, replication recovery and chromosome stability. Mechanistically, S1133 phosphorylation of WRN is dispensable for relocalization in foci but is involved in the interaction with the MRE11 complex. Loss of WRN phosphorylation negatively affects MRE11 foci formation and acts in a dominant negative manner to prevent long-range resection altogether, thereby licensing NHEJ at collapsed forks. Collectively, we unveil a CDK1-dependent regulation of the WRN-DNA2-mediated resection and identify an undescribed function of WRN as a DSB repair pathway switch.
PMID: 27634057 [PubMed - in process]
印刷用ページを開く Endnote用テキストダウンロード