絞り込み

16642

広告

小児がん患者 拠点病院への集約 十分に進まず (NHK)

子どもが亡くなる病気で最も多い小児がんについて、国は、適切な医療や支援を受けられるようにしようと、全国15か所にある拠点病院への患者の集約を進めていますが、国立...

  1. 光合成で酸素できる仕組み解明 岡山大チー...
  2. 日本原電に3500億円支援 (デイリース...
  3. 「抗菌薬不足」に解決策はあるか? (日経...
  4. ガイドラインにもお国柄あり? (日経BP...

ニュース一覧

Mutations in GBA1 are a well-established risk factor for Parkinson disease (PD). GBA-associated PD (GBA-PD) may have a higher burden of nonmotor symptoms than idiopathic PD (IPD). We sought to characterize the relationship between GBA-PD and neuropsychiatric symptoms. Subjects were screened for common GBA1 mutations. GBA-PD (n=31) and non-carrier (IPD; n=55) scores were compared on the Unified Parkinson Disease Rating Scale (UPDRS), Montreal Cognitive Assessment (MoCA), Beck Depression Inventory (BDI), and the State-Trait Anxiety Index (STAI). In univariate comparisons, GBA-PD had a greater prevalence of depression (33.3%) versus IPD (13.2%) (p<0.05). In regression models controlling for age, sex, disease duration, motor disability, and MoCA score, GBA-PD had an increased odds of depression (OR 3.66, 95% CI 1.13-11.8) (p=0.03). Post-hoc analysis stratified by sex showed that, among men, GBA-PD had a higher burden of trait anxiety and depression than IPD; this finding was sustained in multivariate models. Among women, GBA-PD did not confer greater psychiatric morbidity than IPD. These results suggest that GBA1 mutations confer greater risk of neuropsychiatric morbidity in PD, and that sex may affect this association.
PMID: 27772789 [PubMed - in process]
印刷用ページを開く Endnote用テキストダウンロード