絞り込み

16642

広告

最高峰の野生生物写真コンテスト、驚く受賞作15点 (日経BP)

チベットスナギツネがマーモットに襲いかかる直前の瞬間を、中国の写真家バオ・ヨンチン氏がとらえた。「ワイルドライフ・フォトグラファー・オブ・ザ・イヤー」で大賞に輝...

  1. エコノミークラス症候群の予防のために
  2. 吉村・大阪府知事「保健所で適切に対応」 ...
  3. マッチング最終、市中病院マッチ者が6割超...
  4. ユニ・チャーム、紙おむつ再生 (デイリー...

ニュース一覧

Why Human Papillomaviruses Activate the DNA Damage Response (DDR) and How Cellular and Viral Replication Persists in the Presence of DDR Signaling.

著者 Bristol ML , Das D , Morgan IM
Viruses.2017 Sep 21 ; 9(10):.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (24view , 0users)

Full Text Sources

Miscellaneous

Human papillomaviruses (HPV) require the activation of the DNA damage response (DDR) in order to undergo a successful life cycle. This activation presents a challenge for the virus and the infected cell: how does viral and host replication proceed in the presence of a DDR that ordinarily arrests replication; and how do HPV16 infected cells retain the ability to proliferate in the presence of a DDR that ordinarily arrests the cell cycle? This raises a further question: why do HPV activate the DDR? The answers to these questions are only partially understood; a full understanding could identify novel therapeutic strategies to target HPV cancers. Here, we propose that the rapid replication of an 8 kb double stranded circular genome during infection creates aberrant DNA structures that attract and activate DDR proteins. Therefore, HPV replication in the presence of an active DDR is a necessity for a successful viral life cycle in order to resolve these DNA structures on viral genomes; without an active DDR, successful replication of the viral genome would not proceed. We discuss the essential role of TopBP1 in this process and also how viral and cellular replication proceeds in HPV infected cells in the presence of DDR signals.
PMID: 28934154 [PubMed - in process]
印刷用ページを開く Endnote用テキストダウンロード