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FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation.

著者 Tu CF , Wu MY , Lin YC , Kannagi R , Yang RB
Breast Cancer Res.2017 Oct 05 ; 19(1):111.
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Core fucosylation (addition of fucose in α-1,6-linkage to core N-acetylglucosamine of N-glycans) catalyzed by fucosyltransferase 8 (FUT8) is critical for signaling receptors involved in many physiological and pathological processes such as cell growth, adhesion, and tumor metastasis. Transforming growth factor-β (TGF-β)-induced epithelial-mesenchymal transition (EMT) regulates the invasion and metastasis of breast tumors. However, whether receptor core fucosylation affects TGF-β signaling during breast cancer progression remains largely unknown.
PMID: 28982386 [PubMed - in process]
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