In recent years, rapidly accumulating evidence implicates forkhead box C1 () in cancer, especially in studies of basal-like breast cancer (BLBC). Other studies have followed suit, demonstrating thatis not only a major player in this breast cancer subtype, but also in hepatocellular carcinoma (HCC), endometrial cancer, Hodgkin's lymphoma (HL), and non-Hodgkin's lymphoma (NHL). Thegene encodes a transcription factor that is crucial to mesodermal, neural crest, and ocular development, and mutations found inhave been found to cause dominantly inherited Axenfeld-Rieger Syndrome (ARS). Interestingly, whilemissense mutations that are associated with ARS usually reduce gene activity, increasedfunction now appears to be often linked to more aggressive cancer phenotypes in BLBC, HCC, HL, and NHL. This review discusses not only the role ofin cancer cell progression, proliferation, differentiation, and metastasis, but also the underlying mechanisms of howcan contribute to aggressive cancer phenotypes.
PMID: 29487724 [PubMed]