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Blocking H1/H2 histamine receptors inhibits damage/fibrosis in Mdr2mice and human cholangiocarcinoma tumorigenesis.

著者 Kennedy L , Hargrove L , Demieville J , Karstens A , Jones H , DeMorrow S , Meng F , Invernizzi P , Bernuzzi F , Alpini G , Smith S , Akers A , Meadows V , Francis H
Hepatology.2018 Mar 30 ; ():.
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Primary Sclerosing Cholangitis (PSC) patients are at risk of developing cholangiocarcinoma (CCA). We have shown that: (i) histamine (HA) increases biliary hyperplasia via H1/H2 histamine receptors (HRs) and (ii) HA levels increase and mast cells (MCs) infiltrate during PSC and CCA. We aimed to examine the effects of chronic treatment with H1/H2HR antagonists on PSC and CCA.
PMID: 29601088 [PubMed - as supplied by publisher]
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