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ニホンザル 餌を得るため2匹が協力 初めて確認か 阪大が実験 (NHK)

2匹のニホンザルが餌を獲得するために互いに協力して行動できることを大阪大学の研究グループが実験で確認し、ニホンザルの新たな側面として注目されています。 実験を進...

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Probing the Inhibitor versus Chaperone Properties of sp²-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease.

著者 Mena-Barragán T , García-Moreno MI , Sevšek A , Okazaki T , Nanba E , Higaki K , Martin NI , Pieters RJ , Fernández JMG , Mellet CO
Molecules.2018 Apr 17 ; 23(4):.
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A series of sp²-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern (d- or l-), the architecture of the glycone skeleton, and the nature of the nonglycone substituent has been synthesized and assayed for their inhibition properties towards commercial glycosidases. On the basis of their affinity and selectivity towards GH1 β-glucosidases, reducing and nonreducing bicyclic derivatives having a hydroxylation profile of structural complementarity with d-glucose and incorporating an -octyl-isourea or -isothiourea segment were selected for further evaluation of their inhibitory/chaperoning potential against human glucocerebrosidase (GCase). The 1-deoxynojirimycin (DNJ)-related nonreducing conjugates behaved as stronger GCase inhibitors than the reducing counterparts and exhibited potent chaperoning capabilities in Gaucher fibroblasts hosting the neuronopathic G188S/G183W mutation, the isothiourea derivative being indeed one of the most efficient chaperone candidates reported up to date (70% activity enhancement at 20 pM). At their optimal concentration, the four selected compounds promoted mutant GCase activity enhancements over 3-fold; yet, the inhibitor/chaperoning balance became unfavorable at much lower concentration for nonreducing as compared to reducing derivatives.
PMID: 29673163 [PubMed - in process]
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