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DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex.

著者 Gasparoni G , Bultmann S , Lutsik P , Kraus TFJ , Sordon S , Vlcek J , Dietinger V , Steinmaurer M , Haider M , Mulholland CB , Arzberger T , Roeber S , Riemenschneider M , Kretzschmar HA , Giese A , Leonhardt H , Walter J
Epigenetics Chromatin.2018 Jul 25 ; 11(1):41.
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Epigenome-wide association studies (EWAS) based on human brain samples allow a deep and direct understanding of epigenetic dysregulation in Alzheimer's disease (AD). However, strong variation of cell-type proportions across brain tissue samples represents a significant source of data noise. Here, we report the first EWAS based on sorted neuronal and non-neuronal (mostly glia) nuclei from postmortem human brain tissues.
PMID: 30045751 [PubMed - in process]
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