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Enhanced and controlled chromatin extraction from FFPE tissues and the application to ChIP-seq.

著者 Zhong J , Ye Z , Clark CR , Lenz SW , Nguyen JH , Yan H , Robertson KD , Farrugia G , Zhang Z , Ordog T , Lee JH
BMC Genomics.2019 Mar 29 ; 20(1):249.
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Epigenetic dysregulation is involved in the etiology and progression of various human diseases. Formalin-fixed paraffin-embedded (FFPE) samples represent the gold standard for archiving pathology samples, and thus FFPE samples are a major resource of samples in clinical research. However, chromatin-based epigenetic assays in the clinical settings are limited to fresh or frozen samples, and are hampered by low chromatin yield in FFPE samples due to the lack of a reliable and efficient chromatin preparation method. Here, we introduce a new chromatin extraction method from FFPE tissues (Chrom-EX PE) for chromatin-based epigenetic assays.
PMID: 30922218 [PubMed - in process]
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