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Deciphering the intersystem crossing in near-infrared BODIPY photosensitizers for highly efficient photodynamic therapy.

著者 Miao X , Hu W , He T , Tao H , Wang Q , Chen R , Jin L , Zhao H , Lu X , Fan Q , Huang W
Chem Sci.2019 Mar 14 ; 10(10):3096-3102.
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Deciphering singlet-to-triplet intersystem crossing (ISC) in organic near-infrared photosensitizers (PSs) is of fundamental importance in the designing of high-performance PSs to boost the clinical usage of photodynamic therapy (PDT). However, in-depth investigations of the ISC dynamics in near-infrared PSs have not been performed to date. Here, systematical investigations of the ISC dynamics in organic near-infrared BODIPY derivatives are presented, in which a multi-channel yet remarkably efficient ISC process is revealed by ultrafast femtosecond transient absorption (fs-TA) spectroscopy and theoretical calculation. The fs-TA verifies an exceptionally enhanced ISC efficiency ( = 91%) in iodine-substituted BODIPY () which is further supported by the calculation results. This endows with an ultrahigh singlet oxygen quantum yield ( = 88%), thus enabling a proof-of-concept application of highly efficient PDT under ultralow near-infrared light power density (10 mW cm). The in-depth understanding of ISC dynamics in organic near-infrared materials may provide valuable guidance in the designing of novel organic theranostic materials for clinical cancer treatment.
PMID: 30996892 [PubMed]
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