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新型ウイルス 封鎖から1か月 先行きの見えない街 中国 武漢 (NHK)

新型コロナウイルスの感染が広がっている中国で状況が最も深刻な湖北省武漢では、事実上、街が封鎖される措置がとられてから23日で1か月になります。住民は外出を厳しく...

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Could postnatal age-related uridine diphosphate glucuronic acid be a rate-limiting factor in the metabolism of morphine during the first week of life?

著者 Liu T , Lewis TR , Moore JN , Kraft WK , Gauda EB , Sartori D , Moody DE , Gobburu JVS , Ivaturi V この記事をPubMed上で見るPubMedで表示
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Neonates experience dramatic changes in the disposition of drugs after birth due to enzyme maturation and environmental adjustment, challenging therapeutic decision making. In this research, we establish postnatal age, postmenstrual age, and body weight as physiologically reasonable predictors of morphine's clearance in neonates. By integrating knowledge of bilirubin, morphine and other drugs metabolized by glucuronidation pathways from previously published studies, we hypothesize that a postnatal age dependent sugar, uridine diphosphate glucuronic acid, plays an important role in the metabolism of morphine during the first week of life. This finding can be extended to other drugs metabolized by UGT pathways in neonates and thus has important clinical implications for the use of drugs in this population. This article is protected by copyright. All rights reserved.
PMID: 31044547 [PubMed - as supplied by publisher]
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