絞り込み

16646

広告

未来の科学の夢絵画展、文科大臣賞に愛知の石野さん (朝日新聞)

文部科学大臣賞の「はばのかわるエスカレーター」=愛知県岡崎市立六名小5年、石野雅宜さん画 [PR] 子どもが自由な発想で夢を描く「第42回未来の科学の夢絵画展」...

  1. NPhA、調剤アシスト研修の申し込み受付...
  2. 「服用薬剤調整支援料2」が新設された意味...
  3. 第105回薬剤師国試、104回よりもかな...
  4. [企業] 武田薬品がPvP Biolog...

ニュース一覧

Polyamine synthesis enzyme AMD1 is closely associated with tumorigenesis and prognosis of human gastric cancers.

著者 Xu L , You X , Cao Q , Huang M , Hong LL , Chen XL , Lei L , Ling ZQ , Chen Y
Carcinogenesis.2019 May 29 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (3view , 0users)

Full Text Sources

Adenosylmethionine decarboxylase 1 (AMD1) is a key enzyme involved in biosynthesis of polyamines includingspermidine and spermine. The potential function of AMD1 in human gastric cancers is unknown. We analyzed AMD1 expression level in 319 human gastric cancers samples together with the adjacent normal tissues. The protein expression level of AMD1 was significantly increased in human gastric cancer samples compared with their corresponding para-cancerous histological normal tissues (P<0.0001). The expression level of AMD1 was positively associated with Helicobactor pylori 16sRNA (P<0.0001), tumor size (P<0.0001), tumor differentiation (P<0.05), tumor venous invasion (P<0.0001), tumor lymphatic invasion (P<0.0001), blood vessel invasion (P<0.0001), and TNM stage (P<0.0001). Patients with high expression of AMD1 had a much shorter overall survival than those with normal/low expression of AMD1. Knockdown of AMD1 in human gastric cancer cells suppressed cell proliferation, colony formation and cell migration. In a tumor xenograft model, knockdown of AMD1 suppressed the tumor growth in vivo. Inhibition of AMD1 by an inhibitor SAM486A in human gastric cancer cells arrested cell cycle progression during G1-to-S transition. Collectively, our studies at the cellular, animal and human levels indicate that AMD1 has a tumorigenic effect on human gastric cancers and affect the prognosis of the patients.
PMID: 31140554 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード