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新型肺炎 空港や港の検疫所でもウイルス検査実施へ 厚労省

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Impacts of the MHC class I-like XNC10 and innate-like T cells on tumor tolerance and rejection in the amphibian Xenopus.

著者 Banach M , Edholm ES , Gonzalez X , Benraiss A , Robert J
Carcinogenesis.2019 Jun 01 ; ():.
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The conditions that lead to anti- or pro-tumor functions of natural killer T (NKT) cells against mammalian tumors are only partially understood. Therefore, insights into the evolutionary conservation of NKT and their analogs - innate-like T (iT) cells may reveal factors that contribute to tumor eradication. As such, we investigated the amphibian Xenopuslaevis iT cells and interacting MHC class I-like (XNC or mhc1b.L) genes against ff-2 thymic lymphoid tumors. Upon ff-2 intraperitoneal transplantation into syngeneic tadpoles, two iT cell subsets iVα6 and iVα22, characterized by an invariant T cell receptor (iTCR) α chain rearrangement - Vα6-Jα1.43 and Vα22-Jα1.32, respectively, were recruited to the peritoneum, concomitant with a decreased level of these transcripts in the spleen and thymus. To address the hypothesize that different iT cell subsets have distinct, possibly opposing, roles upon ff-2 tumor challenge, we determined whether ff-2 tumor growth could be manipulated by impairing Vα6 iT cells or by deleting their restricting element, the XNC gene - XNC10 (mhc1b10.1.L) on ff-2 tumors. Accordingly, the in vivo depletion of Vα6 iT cells using XNC10-tetramers enhanced tumor growth, indicating Vα6 iT cells-mediated anti-tumor activities. However, XNC10-deficient transgenic tadpoles that also lack Vα6 iT cells were resistant to ff-2 tumors, uncovering a potential new function of XNC10 besides Vα6 iT cell development. Furthermore, the CRISPR/Cas9-mediated knockout of XNC10 in ff-2 tumors broke the immune tolerance. Together, our findings demonstrate the relevance of XNC10/iT cell axis in controlling Xenopus tumor tolerance or rejection.
PMID: 31155639 [PubMed - as supplied by publisher]
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