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新型ウイルス肺炎 患者440人 死者9人 重症102人 医師も感染か

中国で感染が拡大する新型のコロナウイルスによるとみられる肺炎について中国政府は、患者は440人に増え、死者は9人、症状が重い患者は102人に上ると発表しました。...

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Systematically characterize the clinical and biological significances of 1p19q genes in 1p/19q non-codeletion glioma.

著者 Chai RC , Zhang KN , Chang YZ , Wu F , Liu YQ , Zhao Z , Wang KY , Chang YH , Jiang T , Wang YZ
Carcinogenesis.2019 Jun 03 ; ():.
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1p/19q codeletion, which leads to the abnormal expression of 1p19q genes in oligodendroglioma, is associated with chemosensitivity and favorable prognosis. Here, we aimed to explore the clinical implications of 1p19q gene expression in 1p/19q non-codel gliomas. We analyzed expression of 1p19q genes in 668 1p/19q non-codel gliomas obtained from The Cancer Genome Atlas (TCGA) (n = 447) and the Chinese Glioma Genome Atlas (CGGA) (n = 221) for training and validation, respectively. The expression of 1p19q genes was significantly correlated with the clinicopathological features and overall survival (OS) of 1p/19q non-codel gliomas. Then, we derived a risk signature of 25 selected 1p19q genes that not only had prognosis value in total 1p/19q non-codel gliomas but also had prognosis value in stratified gliomas. The prognosis value of the risk signature was superior than known clinicopathological features in 1p/19q non-codel gliomas and was also highly associated with the following features: loss of CDKN2A/B copy number in mutant-IDH-astrocytoma; TERT promoter mutation, combined chromosome 7 gain / chromosome 10 loss, and EGFR amplification in wildtype-IDH-astrocytoma; Classical and Mesenchymal subtypes in glioblastoma. Furthermore, genes enriched in the biological processes of cell division, extracellular matrix, angiogenesis significantly correlated to the signature risk-score, and this is also supported by the immunohistochemistry and cell biology experiments. In conclusion, the expression profile of 1p19q genes is highly associated with the malignancy and prognosis of 1p/19q non-codel gliomas. A 25-1p19q-gene signature has powerfully predictive value for both malignant molecular pathological features and prognosis across distinct subgroups of 1p/19q non-codel gliomas.
PMID: 31157866 [PubMed - as supplied by publisher]
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