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Autologous Stem Cell Transplantation for Multiple Myeloma: Growth Factor Matters.

著者 Chen J , Pan J , Zhan T , Tuazon S , Saini N , O'Hara W , Filicko-O'Hara J , Klumpp T , Kasner M , Carabasi M , Porcu P , Wagner JL この記事をPubMed上で見るPubMedで表示
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Engraftment syndrome (ES) is a known complication of autologous hematopoietic stem cell transplant during neutrophil recovery. There is a limited amount of data available comparing the incidence of ES with post-transplant G-CSF versus GM-CSF, specifically in patients with multiple myeloma. Our retrospective review of 156 patients at a single center showed that GM-CSF was associated with a higher incidence of ES compared with G-CSF (32% vs. 8% of patients, p<0.001) and that development of ES was associated with 32.9% (p<0.001) longer hospital stay. This suggests that the choice of growth factor could possibly contribute to the development of ES and the associated costs of increased medical care.
PMID: 31173899 [PubMed - as supplied by publisher]
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