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小児がん患者 拠点病院への集約 十分に進まず (NHK)

子どもが亡くなる病気で最も多い小児がんについて、国は、適切な医療や支援を受けられるようにしようと、全国15か所にある拠点病院への患者の集約を進めていますが、国立...

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[Association between mitochondrial haplogroups and neurocognitive disorder in HIV positive individuals].

著者 Zhao D , Lin HJ , Wei Q , Chen XX , Ning CX , Qiao XT , Xu YY , Shen WW , Ding YY , He N
Zhonghua Liu Xing Bing Xue Za Zhi.2019 May 10 ; 40(5):505-509.
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To investigate the distribution of mitochondrial haplogroups and their correlation with neurocognitive disorder (NCD) in HIV positive individuals. Baseline data were from the prospective cohort study of comparative HIV and aging research in Taizhou of Zhejiang province from January to December, 2017. A cross-sectional survey was performed in 448 HIV positive individuals. Sanger method was used for the sequencing and genotyping of whole mitochondrial genome of HIV positive individuals. NCD prevalence in the HIV positive individuals was assessed by Mini-mental State Examination (MMSE) in questionnaire interviews. Multivariable logistic regression analysis was performed to assess the associations between mtDNA haplogroups and NCD. In this sample, mitochondrial haplogroups D (19.6%, 88/448), B (19.4%, 87/448) and F(17.0%, 76/448) were the most predominant haplogroups. The overall prevalence rate of NCD was 20.3% (91/448), and was high in haplogroups A (23.1%, 9/39), D (21.6%, 19/88), F (26.3%, 20/76) and M7 groups (26.1%, 12/46), respectively. In multivariable logistic regression analysis after adjusting confounding factors, such as age and gender, compared with haplogroup A, there were no differences in the prevalence rate of NCD among HIV positive individuals with haplogroup B, D, F, M7, M8, N9, and others. The study explored primarily correlation between mitochondrial haplogroups and NCD among HIV positive individuals and suggested that there is no significant association between mitochondrial haplogroups and NCD, but further longitudinal investigation with large sample size of HIV positive population is needed to confirm this finding.
PMID: 31177728 [PubMed - in process]
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