Synthesis of modified 1,5-imino-d-xylitols as ligands for lysosomal -glucocerebrosidase.
Zoidl M , Wolfsgruber A , Schalli M , Nasseri SA , Weber P , Stütz AE , Withers SG , Wrodnigg TM
Monatshefte für Chemie
Modified 1,5-dideoxy-1,5-imino-d-xylitol analogues with different substitution patterns involving position C-1 and/or the ring nitrogen were prepared, which were designed to serve as precursors for the preparation of iminoxylitol-based ligands and tools for the elucidation and modulation of human lysosomal -glucocerebrosidase. Biological evaluation of the synthesized glycomimetics with a series of glycoside hydrolases revealed that these substitution patterns elicit excellent -glucosidase selectivities.
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