GBA1-associated parkinsonism: new insights and therapeutic opportunities.
Ryan E , Seehra G , Sharma P , Sidransky E
Current opinion in neurology
GBA1 mutations, which result in the lysosomal disorder Gaucher disease, are the most common known genetic risk factor for Parkinson disease and Dementia with Lewy Bodies (DLB). The pathogenesis of this association is not fully understood, but further elucidation of this link could lead to new therapeutic options.
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