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A nano-sized gel-in-oil suspension for transcutaneous protein delivery.

著者 Hardiningtyas SD , Nagao S , Yamamoto E , Shirakigawa N , Wakabayashi R , Goto M , Ijima H , Kamiya N
Int J Pharm.2019 Jul 02 ; ():118495.
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We developed a new oil-based delivery system for transdermal protein delivery, a gel-in-oil (G/O) nanosuspension, where gelatin-based hydrogel was coated with hydrophobic surfactants. The high entrapment efficiency of a model protein, phycocyanin (PC), into nano-sized gelatin hydrogel particles was achieved. Spectroscopic evaluation of PC suggested that the G/O nanosuspension could retain the functional form of PC in isopropyl myristate. In vitro skin permeation studies showed that the G/O nanosuspension facilitated the delivery of PC through the stratum corneum of Yucatan micropig skin.
PMID: 31276761 [PubMed - as supplied by publisher]
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