絞り込み

16641

広告

【動画】今日はどうされましたか? (日経BP)

診察室やカンファレンスなどでよく使う医療英語のエッセンスを、今日も楽しく学んでいきましょう。 今日のトレーニングは「最初の3単語」です。診察室でよく使うこのフレ...

  1. 地域包括ケア病棟 (日経BP)
  2. 預かった保険証を紛失! 心当たりをたどる...
  3. 製薬会社からのギフトは処方に影響するか?...
  4. ホルモン受容体陽性進行乳癌へのCDK4/...

ニュース一覧

Complement component C5a induces aberrant epigenetic modifications in renal tubular epithelial cells accelerating senescence by Wnt4/βcatenin signaling after ischemia/reperfusion injury.

著者 Castellano G , Franzin R , Sallustio F , Stasi A , Banelli B , Romani M , De Palma G , Lucarelli G , Divella C , Battaglia M , Crovace A , Staffieri F , Grandaliano G , Stallone G , Ditonno P , Cravedi P , Cantaluppi V , Gesualdo L
Aging (Albany NY).2019 Jul 08 ; 11():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (3view , 0users)

Full Text Sources

Miscellaneous

Epigenetic mechanisms, such as DNA methylation, affect tubular maladaptive response after Acute Kidney Injury (AKI) and accelerate renal aging. Upon ischemia/reperfusion (I/R) injury, Complement activation leads to C5a release that mediates damage; however, little is known about the effect of C5a-C5a Receptor (C5aR) interaction in Renal Tubular Epithelial Cells (RTEC).Through a whole-genome DNA methylation analysis in cultured RTEC, we found that C5a induced aberrant methylation, particularly in regions involved in cell cycle control, DNA damage and Wnt signaling. The most represented genes were , and . C5a stimulation of RTEC led to up-regulation of SA-β Gal and cell cycle arrest markers such as p53 and p21. C5a increased also , and gene expression, consistent with SASP development. In accordance, in a swine model of renal I/R injury, we found the increased expression of Wnt4 and βcatenin correlating with SA-β Gal, p21, p16 and IL-6 positivity. Administration of Complement Inhibitor (C1-Inh), antagonized SASP by reducing SA-β Gal, p21, p16, IL-6 and abrogating Wnt4/βcatenin activation.Thus, C5a affects the DNA methylation of genes involved in tubular senescence. Targeting epigenetic programs and Complement may offer novels strategies to protect tubular cells from accelerated aging and to counteract progression to Chronic Kidney Disease.
PMID: 31284268 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード