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Dual Therapy with Vonoprazan and Amoxicillin Is as Effective as Triple Therapy with Vonoprazan, Amoxicillin and Clarithromycin for Eradication of Helicobacter pylori.

著者 Furuta T , Yamade M , Kagami T , Uotani T , Suzuki T , Higuchi T , Tani S , Hamaya Y , Iwaizumi M , Miyajima H , Umemura K , Osawa S , Sugimoto K
Digestion.2019 Aug 21 ; ():1-9.
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Vonoprazan (VPZ) is the first clinically available potassium competitive acid blocker. This class of agents provides faster and more potent acid inhibition than proton pump inhibitors. Most strains of Helicobacter pylori are sensitive to amoxicillin. We hypothesized that dual therapy with VPZ and amoxicillin would provide the sufficient eradication rate for H. pylori infection. To evaluate this, we compared the eradication rate by the dual VPZ/amoxicillin therapy with that by the standard triple VPZ/amoxicillin/clarithromycin therapy.
PMID: 31434101 [PubMed - as supplied by publisher]
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