絞り込み

16645

広告

A Combination of Pharmacophore and Docking-based Virtual Screening to Discover new Tyrosinase Inhibitors.

著者 Vittorio S , Seidel T , Germanò MP , Gitto R , Ielo L , Garon A , Rapisarda A , Pace V , Langer T , De Luca L
Mol Inform.2019 Sep 11 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

スターを付ける スターを付ける     (3view , 0users)
Melanogenesis controls the formation of melanin pigment whose overproduction is related to various hyperpigmentary disorders in humans. Tyrosinase is a type-3 copper enzyme involved in the rate limiting step of melanin synthesis, therefore its inhibition could represent an efficient way for the development of depigmenting agents. In this work, a combination of pharmacophore and docking-based studies has been employed to screen two in-house 3D compound databases containing about 2,000 molecules from natural and synthetic sources. As result we selected two "hit compounds" which proved to inhibit tyrosinase activity showing IC values in the micromolar range.
PMID: 31508903 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード